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There is no reason you should need to know this unless you are a drug addict and on methadone already. If you are taking methadone, you should not be prescribed percocets. But if you are looking for ways to get higher yes, they work together, just adds to the effects of each other.

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13y ago
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11y ago

No, if you are going to mix them you would want to take the percocet first as it has a more euphoric effect than methadone. If you take the methadone first, it will block out the percocet effect (or most of it). Methadone is much more powerful and longer lasting than percocet in terms of opioid strength so it will overpower the percocet. In my personal opinion from experience, taking both together is absolutely pointless. These two drugs do not really mix well together and will not add to your "high" if you take both. WHatever medication you take first is the effect you will feel.

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10y ago

Yes but its best if your on a small dose of methadone and take the percocet after as needed for breakthrough pain... Methadone blocks ur opiate receptors so ur not gonna get extra high... Neither drug will.increase the euphoric effect of the other... In fact methadone will make it harder to feel.any euphoric effect caused by an opiate

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Q: Should you take methadone before percocet?
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