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Neurotransmitters diffuse across the synaptic cleft (a very short distance) and bind to receptor proteins on the postsynaptic membrane. Excitatory neurotransmitters cause sodium ions to move through receptor proteins depolarizing the membrane. Inhibitory neurotransmitters do not depolarize the postsynaptic membrane. Thus, the condition that would produce inhibition at synapse is called HYPERPOLARIZATION.

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