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Meningitis, by definition, is an inflammatory process of the meninges, which constitute the blood brain barrier (BBB). Inflammation makes the blood brain barrier more permeable to chemicals, such as antibiotics. Under normal circumstances, penicillin does not cross the BBB very well, but when inflamed, it can cross more readily.
Wiki User
∙ 14y ago
Wiki User
∙ 11y agoAntibiotics that crosses BBB-
1 Cephalosporins:eg. Ceftriaxone, Cefotaxime, ceftazidime, cefepime
2) Penicillins: Ampicillin
3 Antifungals: Amp B with flucytosine, Fluconazole
4 Vancomycin
5 Anti-tuberculous drugs. eg. INH
- 4 years ago
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What type of drugs can cross the blood brain barrier?
Antidepressants, alcohol, cocaine
Do chemotherapy drugs affect neurons?
some of the drugs can cross blood-brain barrier, so it can affect neurons too.
What kinds of drug need to be lipophilic?
Drugs which are administered percutaneously, sublingually, or have to cross the blood brain barrier have to be lipophilic.
What protects the brain tissues from the effects of certain drugs?
The blood-brain-barrier.
Why are most therapeutic drugs unable to cross the blood brain barrier?
The blood-brain barrier is an actual filter. Most molecules are too big to squeeze through it! This protects the delicate brain cells from a lot of toxins and poisons. It also keeps some chemicals inside the brain, where they can act to the most good.
What ORGAN blocks entrance of many drugs because of a barrier similar to the blood brain barrier?
Spleen
What is the blood brain barrier is effective against?
The blood brain barrier is effective again harmful chemicals in the blood and bacteria infections from reaching the brain. Many of the drugs on the street breach this barrier. K12 or bath salts is a very good example of the damage breaching this barrier can cause.
What prevents many drugs from penetrating the brain?
The Blood-Brain Barrier (BBB). This is actually a good website describing it : http://faculty.washington.edu/chudler/bbb.html
Does the brain liver heart or kidney contain anatomical barriers that limit some drugs from gaining access?
Yes, the brain has anatomical barriers that limit the entry of drugs. The blood-brain barrier (BBB) is a highly selective barrier formed by specialized endothelial cells that line the blood vessels in the brain. It prevents the passage of certain substances, including many drugs, from entering the brain tissue. The liver also has its own protective barriers, such as the hepatocyte membrane, which regulates the absorption and distribution of drugs.
Describe the role of the choroid plexus in the blood-brain barrier?
The choroid plexus is in contact with the cells lining the ventricles, which helps in the formation of cerebrospinal fluid. The capillaries of the choroid plexus differ significantly from those found elsewhere in the body. As a result, drugs carried in the bloodstream may not effectively penetrate brain tissue. This phenomenon is referred to as the blood-brain barrier. In short, the choroid plexus helps create the barrier, as it is through it's capillaries that the barrier is formed.
Which method of drug use effects the CNS the quickest?
I would guess IV, but inhalation of gaseous form would be close. Some drugs do not pass the blood brain barrier however.
Why not all drugs are able to effect the brain?
Drugs impact the brain because it causes abnormal growth which eventually forms tiny, almost mircroscopic little short hairy gnomes inside the oppicatal canal of the coccxy. This gnomes are very irritable but can be removed surgically. The gnomes will play padie wac on your pariential lobe. If you listen close enough you can hear the awsome reggie beat their banging out. After awhile the beat will infect your nerves, which becomes a pounding. Take two of theze and youll be fine.
