What are disadvantage of tincture?

Chemically speaking, ethanol possesses a profound intrinsic denaturing and inert rendering quality. This quality accounts for a large part of ethanol's anti-microbial properties. This denaturing and inert rendering quality also has an undesired effect on many extracted botanical constituents. For instance, alcohol intrinsically fractures and denatures many highly complex aromatic compounds and denatures many extracted for polysaccharides. Other constituents are likewise subjected to denaturing and being rendered inert. The basic tenets of chemistry teach that anytime a biologically viable component is denatured or rendered inert, it will reduce or negate the prior biological viability. This factor needs to be seriously considered and weighed by the clinician or consumer when determining the hoped for biological viability of an ethanol-based botanical tincture both as to sought for efficacy and dosage considerations.

Ether and propylene glycol tinctures are not suitable for internal consumption and are instead used in such preparations as creams or ointments.