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Spherocytes are abnormally round red blood cells that lack the central pallor seen in normal red blood cells. They are often associated with certain medical conditions such as autoimmune hemolytic anemia. Spherocytes are more fragile than normal red blood cells and may be removed from circulation more rapidly, leading to hemolytic anemia.
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What is spherocytes?
Spherocytes are abnormally shaped red blood cells that appear more round and compact than their normal biconcave disc shape. They can result from conditions like autoimmune hemolytic anemia, hereditary spherocytosis, or certain infections. Spherocytes have increased fragility and decreased flexibility, which may lead to their premature destruction and contribute to anemia.
What four properties of blood affect the esr?
The four properties of blood that affect the ESR (erythrocyte sedimentation rate) are the concentration of fibrinogen, the size and shape of red blood cells, the presence of inflammatory proteins, and the presence of abnormal proteins like sickle cells or spherocytes. These properties can impact the rate at which red blood cells settle in a tube, affecting the ESR measurement.
What does that mean if you MCH test is high?
That is not possible. There is something wrong with your results. Tell your MLT/MT to rerun your CBC/MCH test. Spherocytes can cause MCH/MCHC to go high, but it is impossible. Spherocyte is a small red blood cell that have no central pallor
What is spherocytes?
Spherocytes are abnormally shaped red blood cells that appear more round and compact than their normal biconcave disc shape. They can result from conditions like autoimmune hemolytic anemia, hereditary spherocytosis, or certain infections. Spherocytes have increased fragility and decreased flexibility, which may lead to their premature destruction and contribute to anemia.
What does a low MCHC count mean-31.7?
bordeline of macrocytic anemia, which could be a folic acid deficiency, liver disease, hereditary spherocytes or B-12 deficiency
When comparing blood smears of patient with intact spleens and those of patients without spleens the blood smears of patients without spleens will likely reveal what?
Blood smears of patients without spleens are likely to show Howell-Jolly bodies, which are nuclear remnants normally removed by the spleen. Additionally, there may be an increase in target cells and spherocytes due to altered red blood cell morphology. This can be a diagnostic indicator of asplenia.
What four properties of blood affect the esr?
The four properties of blood that affect the ESR (erythrocyte sedimentation rate) are the concentration of fibrinogen, the size and shape of red blood cells, the presence of inflammatory proteins, and the presence of abnormal proteins like sickle cells or spherocytes. These properties can impact the rate at which red blood cells settle in a tube, affecting the ESR measurement.
What does that mean if you MCH test is high?
That is not possible. There is something wrong with your results. Tell your MLT/MT to rerun your CBC/MCH test. Spherocytes can cause MCH/MCHC to go high, but it is impossible. Spherocyte is a small red blood cell that have no central pallor
Nursing responsibilities for patient before and after Complete blood count?
Pretest:Positively identify the patient using at least two unique identifiers before providing care, treatment, or services.Patient Teaching:Inform the patient this test can assist in evaluating the amount of hemoglobin in the blood to assist in diagnosis and monitor therapy.Obtain a history of the patient's complaints, including a list of known allergens, especially allergies or sensitivities to latex.Obtain a history of the patient's cardiovascular, gastrointestinal, hematopoietic, hepatobiliary, immune, and respiratory systems; symptoms; and results of previously performed laboratory tests and diagnostic and surgical procedures.Note any recent procedures that can interfere with test results.Obtain a list of the patient's current medications, including herbs, nutritional supplements, and nutraceuticalsReview the procedure with the patient. Inform the patient that specimen collection takes approximately 5 to 10 min. Address concerns about pain and explain that there may be some discomfort during the venipuncture.Sensitivity to social and cultural issues, as well as concern for modesty, is important in providing psychological support before, during, and after the procedure.There are no food, fluid, or medication restrictions unless by medical direction.Intratest:If the patient has a history of allergic reaction to latex, avoid the use of equipment containing latex.Instruct the patient to cooperate fully and to follow directions. Direct the patient to breathe normally and to avoid unnecessary movement.Observe standard precautions, and follow the general guidelines. Positively identify the patient, and label the appropriate tubes with the corresponding patient demographics, date, and time of collection. Perform a venipuncture; collect the specimen in a 5-mL lavender-top (EDTA) tube. An EDTA Microtainer sample may be obtained from infants, children, and adults for whom venipuncture may not be feasible. The specimen should be mixed gently by inverting the tube 10 times. The specimen should be analyzed within 24 hr when stored at room temperature or within 48 hr if stored at refrigerated temperature. If it is anticipated the specimen will not be analyzed within 24 hr, two blood smears should be made immediately after the venipuncture and submitted with the blood sample. Smears made from specimens older than 24 hr may contain an unacceptable number of misleading artifactual abnormalities of the RBCs, such as echinocytes and spherocytes, as well as necrobiotic white blood cells.Remove the needle and apply direct pressure with dry gauze to stop bleeding. Observe/assess venipuncture site for bleeding or hematoma formation and secure gauze with adhesive bandage.Promptly transport the specimen to the laboratory for processing and analysis.Post-test:A report of the results will be sent to the requesting HCP, who will discuss the results with the patient.Depending on the results of this procedure, additional testing may be performed to evaluate or monitor progression of the disease process and determine the need for a change in therapy. Evaluate test results in relation to the patient's symptoms and other tests performed.
Blood smear?
DefinitionA blood smear is a blood test that gives information about the number and shape of blood cells.Alternative NamesPeripheral smearHow the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.The blood sample is sent to a lab, where the health care professional looks at it under a microscope. Or, the blood may be examined by an automated machine. The smear shows the number and kinds of white blood cells (differential), abnormally shaped blood cells, and gives a rough estimate of white blood cell and platelet counts.How to prepare for the testNo special preparation is necessary.How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedThis test may be performed as part of a general health exam to help diagnose many illnesses. Or, your doctor may order this test if you have signs of a blood disorder.Other conditions under which the test may be performed:Any known or suspected blood disorderCancerHairy cell leukemiaHemoglobinopathiesMonitoring the side effects of chemotherapyNormal ValuesRed blood cells normally are the same in size and color and have a lighter-colored area in the center. The blood smear is considered normal if there is:Normal appearance of cellsNormal white blood cell differentialNormal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.What abnormal results meanAbnormal results mean there is an abnormality in the size, shape, color, or coating of the red blood cells.Some abnormalities may be graded on a 4-point scale:1+ means 25% of cells are affected2+ means half of cells are affected3+ means 75% of cells are affected4+ means all of the cells are affectedThe presence of target cells may be due to:Decreased osmotic fragilityDeficiency of an enzyme called lecithin cholesterol acyl transferaseHemoglobinabnormalities (hemoglobinopathies)Iron deficiencyLiver diseaseSpleen removalThalassemiaThe presence of sphere-shaped cells (spherocytes) may be due to:Autoimmune hemolytic anemiaHereditary spherocytosisIncreased osmotic fragilityThe presence of elliptocytes may be a sign of hereditary elliptocytosisor hereditary ovalocytosis.The presence of fragmented cells (schistocytes) may be due to:Artificial heart valveDisseminated intravascular coagulationHemolytic uremic syndrome (HUS)Microangiopathic hemolytic anemiaThrombotic thrombocytopenic purpura (TTP)The presence of a type of immature red blood cell called a normoblast may be due to:Cancer that has spread to bone marrowErythroblastosis fetalisLeukoerythroblastic anemia (myelophthisis process)Miliary tuberculosisMyelofibrosisRemoval of spleenSevere hemolysisThalassemiaThe presence of burr cells (echinocytes) may indicate:UremiaThe presence of spur cells (acanthocytes) may indicate:AbetalipoproteinemiaSevere liver diseaseThe presence of teardrop-shaped cells may indicate:Leukoerythroblastic anemiaMyelofibrosisSevere iron deficiencyThalassemiamajorThe presence of Howell-Jolly bodies may indicate:MyelodysplasiaPost-splenectomySickle cell anemiaThe presence of Heinz bodies may indicate:Alpha thalassemiaCongenital hemolytic anemiaG6PD deficiencyUnstable form of hemoglobinThe presence of slightly immature red blood cells (reticulocytes) may indicate:Anemia with bone marrow recoveryHemolytic anemiaHemorrhageThe presence of basophilic stippling may indicate:Lead poisoningMyelofibrosisMyelophthisic processThe presence of sickle cells may indicate sickle cell anemia.What the risks areVeins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.Other risks associated with having blood drawn are slight but may include:Excessive bleedingFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)Special considerationsThe accuracy of this test depends, in part, on the experience of the person looking at the sample. Experienced cell examiners can get a lot of information from the blood smear.ReferencesNewland J. The peripheral blood smear. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 161.Reviewed ByReview Date: 02/09/2010David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
