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Tablet hardness get affected by 3 factors:

1) Material related factors: Compressibility of drug, binder type and concentration, Moisture content of blend etc..

2) Process related factors: Dwell time, Force, Die fill weight

3) Machine related factors: Type of tooling, Vibration of machine

4) Environmental factors: Temperature, Humidity

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Q: What are the factors that can affect hardness of tablets?
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