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Successful cell signaling involves a sender, a signal and a receptor or receiver. There are many different ways in which cell signaling can occur, firstly; there are many different types of signals. These can be classified into two main groups, protein/ polypeptide signals and steroid based or hydrophobic signals. Protein/polypeptide signals can only bind to receptors on the plasma membrane of a cell where as steroid based or hydrophobic are able to pass through (because of their hydrophobic nature) the plasma membrane and attach to receptors within the cytoplasm or nucleus. There are many different receptors and ways that cells then continue on cell signaling but that is the basics of it. Once a signal is bound with its receptor a response occurs.

It goes: sender >> signal >> reception >> transduction >> response Receptors also include ion-channel linked, and G-protien linked receptors. For the enzyme-linked(most common is receptor thyrosine kinase) the signal transduction goes through RAS, MAP kinase to different specific tartget molecules. Also, short gene expression pathways are mediated through STAT and SMAD. Smile over wrong spellings. Absolute Kevin UNCW

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