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It would depend on which particular branch of science.

In all branches of Science you are "standing on the shoulders of giants" as Newton put it. That is you have the advantage of all previous knowledge.

Your own intellect and curiosity is a further valuable tool, including the ability to question 'acknowledged wisdom'.

And of course, your apparatus, including the ability to design a novel apparatus which will address the specific hypothesis.

An electron microscope is used to study atoms, as well as sub-atomic particles, A balance, a tool used to find the mass of a specific object, and finally, the petri dish, which is used to grow bacteria and other microscopic organisms.

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