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1: Excessive destruction of erythrocytes, as in hemolysis, causes excess bilirubin in the blood.
2: Malfunction of Liver Cells (Hepatocytes) because of Liver disease prevents the Liver from excreting bilirubin with bile.
3: Obstruction of bile flow, such as from choledocholithiasis or tumor, prevents bilirubin in bile from being excreted into the duodenum.
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