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The Interstate Commerce Commission (ICC), established in 1887, was significant as the first federal agency created to regulate interstate commerce, particularly focusing on the railroad industry. It aimed to address issues of unfair practices and monopolistic behaviors by ensuring fair rates and eliminating discrimination in freight charges. The ICC set a precedent for federal oversight of transportation and commerce, paving the way for future regulatory bodies and frameworks. Its establishment marked a critical shift towards government intervention in the economy to protect public interests.

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