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There are many reasons for an enlarged liver but most of them do not also cause an enlarged spleen, so we shan't bother with them.

When the liver and spleen are both enlarged from the same cause that is called hepatosplenomegaly. Causes include:

  • Infection:
    • Acute viral hepatitis
    • Infectious mononucleosis
    • Cytomegalovirus
    • Rubella
    • malaria
    • Leishmaniasis
    • Fasciolosis
    • Schistosomiasis or filariasis importans
  • Haematological disease:
    • Myeloproliferative disease
    • Leukaemia
    • Lymphoma
    • Pernicious anaemia
    • Sickle cell anaemia
    • Thalassaemia
    • Myelofibrosis
  • Metabolic disease:
    • Niemann Pick disease
    • Gaucher's disease
    • Hurler's syndrome
  • Chronic liver disease and portal hypertension:
    • Chronic active hepatitis
  • Amyloidosis
  • Acromegaly
  • Systemic lupus erythematosus
  • Sarcoidosis

You see that it is not a highly specific symptom.

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12y ago

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