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Enlargement of the backbone, or vertebrae, can be caused by several factors, including degenerative conditions like osteoarthritis, which leads to bone spurs and disc degeneration. Other causes include conditions such as osteoporosis, which weakens bones, and infections or tumors that can lead to bone growth or swelling. Additionally, inflammatory diseases like ankylosing spondylitis can cause the vertebrae to fuse and enlarge over time. Regular medical evaluation is important for diagnosis and treatment.

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