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The only disease that is altogether gone is smallpox.

But there are a number of diseases that were around in those days that are rarely found today, including polio, scarlet fever, cholera, typhoid fever, typhus, diphtheria, and others. Most of these were made rare by better sanitation, which was introduced starting in the 1890s, antibiotics, introduced in the 1940s, or vaccinations, which began among Europeans about 1800 or a little earlier.

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Q: What diseases were in the 1400s that aren't in the present day and age?
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