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Liver disease (such as cirrhosis or hepatitis) is a medical condition that can increase vitamin B12 in the body. Some myeloproliferative disorders (for example, polycythemia vera and chronic myelocytic leukemia or CML) can also increase vitamin B12 in the body. Vitamin B12 excess is virtually harmful since it is a water-soluble vitamin. It will just be secreted from the body as urine. The conditions themselves are what is cause for concern. The increased vitamin B12 can just be used as an indicator for the disease.

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