What does Como se jueges esto mean in English?

Answer 1

Como se jugues means how does he, she or it play with you? Como se juegues esto is not correct grammar and cannot be translated as described above. Correct usage would be "Como se juega esto?" which means "How do you (does one) play this?"

Answer 2

This is in reference to a game. It means, "How is it played?" Another fairly apt interpretation is, "How do you play it?"