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easiest way to put it is if a meth user is tweeking he/she is high on meth. tweeking is the slang for high on meth. its like how when u smoke pot u get "stoned". use meth and you get "tweeked" or "twacked"

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Lisa Shera

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They’re lurpers. Urban dictionary

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Q: What does it mean when a meth user is tweaking?
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