It means "from the family of Simon" in Italian.
You can read up on the history of the Desimone surname at www.houseofnames.com
Jason DeSimone's birth name is Jason Thomas DeSimone.
Tom DeSimone was born in 1939.
Louis A. DeSimone was born in 1922.
Joseph DeSimone was born in 1964.
Frank DeSimone died in 1967.
Frank DeSimone was born in 1909.
Thomas DeSimone died in 1979.
Thomas DeSimone was born in 1950.
Vincent DeSimone was born in 1918.
Rosario DeSimone died on 1946-07-15.
Rosario DeSimone was born on 1873-12-11.