Disorders, such as Down's Syndrome, are caused by nondisjunction.
Nondisjunction is the failure of chromosome pairs to separate properly during cell division. This can result in an abnormal number of chromosomes in the daughter cells, which can lead to genetic disorders such as Down syndrome.
Chromosomal abnormalities happen when there is an error in cell division. Often a egg or sperm could end up with too many chromosomes or not enough which could result in an abnormality such as the baby being stillborn or being born with health problems.
Nondisjunction occurs during the Anaphase stage of Meiosis. In this stage, the sister chromosomes move to opposite sides of the cell. However, in Nondisjunction one or more set(S) of chromosomes move to the same side of the cell.
You can have a baby with physical/mental deformities or death of the child.
The gene could be moved behind a stronger promoter, the gene could be duplicated, occasionally changes in the 3' and 5' UTRs can result in increased mRNA stability. Chromosomal rearrangement could also influence levels of enhancers and repressors.
If nondisjunction occurs during meiosis the result could be a wide range of mutations. Most likely it would result in mosaicism meaning there will be a mixture of affected cells and non affected cells.
Nondisjunction is the failure of chromosome pairs to separate properly during cell division. This can result in an abnormal number of chromosomes in the daughter cells, which can lead to genetic disorders such as Down syndrome.
You could make a pedigree which could identify carriers of a genetic disorder and individuals with the disorder. You could do blood tests to determine whether a person carries a gene for a particular genetic disorder. You could make a karyotype to determine whether there are any chromosomal abnormalities.
Chromosomal abnormalities happen when there is an error in cell division. Often a egg or sperm could end up with too many chromosomes or not enough which could result in an abnormality such as the baby being stillborn or being born with health problems.
Nondisjunction occurs during the Anaphase stage of Meiosis. In this stage, the sister chromosomes move to opposite sides of the cell. However, in Nondisjunction one or more set(S) of chromosomes move to the same side of the cell.
You can have a baby with physical/mental deformities or death of the child.
The gene could be moved behind a stronger promoter, the gene could be duplicated, occasionally changes in the 3' and 5' UTRs can result in increased mRNA stability. Chromosomal rearrangement could also influence levels of enhancers and repressors.
Chromosomal mutation can have lasting impacts on the person who this happens to. A version of a chromosomal mutation is the mutation that leads to Down's Syndrome.
Down's syndrome is caused by trisomy of the 21st chromosome. This is mostly caused when the chromosome pair fails to separate properly (nondisjunction).
It's more sever in meiotic nondisjunction, since this is the most common way that trisomy 21 (Down syndrome) arises. mitotic nondisjunction is less sever because it means that some cells will be mosaic, meaning they could be normal while some with have the (2n+1) while other cell will be (2n). So, in mitotic nondisjunction it depend how many cells are carrying the extra 21 chromosome. In end of the day they can't be worse than Down syndrome that rose from meiotic nondisjucntion since it has the highest amount of cells carrying trisomy 21.. I hope this helps
A chromosomal anomaly is just as it seems, an abnormality which is an "error"occurring during DNA coding. These errors could occur during gamete (sperm and egg) development (meosis), or possibly later on during normal cell division (mitosis). The later of these scenarios would result in a condition know as mosaicism, which is when not all of one's cells have the anomaly. A genetic disorder, although also a part of one's chromosome which is not functioning as intended, is a genetic "alteration" which is essentially a chromosomal anomaly which can have a traceable family history. however, these are not "errors" as the the genes for these can be found in one's parent's DNA. Chromosomes can be inherited, but, as I said, they are produced by errors, while genetic disorders are acquired when a parent passes on a gene that they carry. Good Luck
Cumulative trauma disordersRepetitive stress injuries Repetitive motion injuries..your welcome! now stop cheating! -_-