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Low red blood cell (RBC) count or low hemoglobin content are both indicators of types of anemia.

With a low RBC count the causes vary, and can include sudden blood loss (as from trauma, including surgery) or an imbalance in the number of red blood cells produced by the bone marrow's reticulocytes versus the number destroyed by hemolysis (natural or disease-induced rupture of red blood cells in the body) or through gradual blood loss (i.e., menstruation in women, or bleeding from a gastric ulcer.)

Low hemoglobin content, indicated by a low hematocrittest result, is often the result of iron deficiency, though some chronic diseases can also cause it.

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