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Inchemistry, an amphoteric substance is one that can react as either an acid or base.

Many metals (such as zinc, tin, lead, aluminium, and beryllium) and most metalloids have amphoteric oxides or hydroxides.

Zinc oxide (ZnO) reacts differently depending on the pH of the solution:

In acids: ZnO + 2H+ → Zn2+ + H2O

In bases: ZnO + H2O + 2OH- → [Zn(OH)4]2-

This effect can be used to separate different cations, such as zinc from manganese.

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