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A therapeutic index refers to eiffernce between the minimum level a medication must reach within the body for it to be effective and the maximum level a drug will reach before a medication causes side effects. For most medications there is a large range between these two values. A narrow therapeutic medication has a must smaller index. Some medications for seizurers or thyroid disease (for example other medications fall into the group too) have a small difference between what dose it required to achieve a proper response and too much that might cause a side effect. All of these medications are dose based on specific patient characteristics and many require frequent blood work or other clinical monitoring. Discuss your questions/ concerns with your pharmacist or other heathcare provider.
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What does low therapeutic index mean?
Drugs with a low therapeutic index have a narrow margin of safety.
Is therapeutic index a useful measure of safety?
It is for certain drugs such as Digoxin as they have such a narrow therapeutic index. For drugs with a wide range of therapeutic index, the best measure of safety is the maximum daily dose, its effect on the patient and what other drugs it interacts with. Ask your pharmacist for specific safety questions on your specific drugs.
What are the nursing responsibilities of digitalis?
Digitalis has a very narrow therapeutic index, therefore, the dose must be carefully be monitored for each patient.
What is the Therapeutic Index of Tobacco?
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What is the therapeutic index of drugs?
The therapeutic index of drugs is the ratio between the amount of drug needed to kill 50% of the cells of the experimental animals and the dose needed for 50% of the cells to respond. The larger the therapeutic index, the safer the drug.
The dose of a drug which kills 50 animals was 60mgkg the dose of a drug which cured 50 animals was20mgkg calculate the therapeutic index of the drug?
The therapeutic index of a drug is determined by dividing the lethal dose (LD50) by the effective dose (ED50). In this case: Therapeutic index = LD50/ED50 = 60mg/kg / 20mg/kg = 3. This means that the drug has a therapeutic index of 3, indicating a relatively safe drug with a wide margin of safety.
What is a composite stock index?
A Stock Market index option is a kind of option. In fact, it is a kind of financial derivative. It is often tied to either a narrow-based index or a broad-based index.
What is narrow therapeutic?
A therapeutic index refers to eiffernce between the minimum level a medication must reach within the body for it to be effective and the maximum level a drug will reach before a medication causes side effects. For most medications there is a large range between these two values. A narrow therapeutic medication has a must smaller index. Some medications for seizurers or thyroid disease (for example other medications fall into the group too) have a small difference between what dose it required to achieve a proper response and too much that might cause a side effect. All of these medications are dose based on specific patient characteristics and many require frequent blood work or other clinical monitoring. Discuss your questions/ concerns with your pharmacist or other heathcare provider.
How calculate therapeutic index?
The therapeutic index (TI) is calculated by dividing the toxic dose (TD50) by the effective dose (ED50) of a drug. Specifically, the formula is TI = TD50 / ED50, where TD50 is the dose at which 50% of the population experiences toxic effects, and ED50 is the dose at which 50% of the population achieves the desired therapeutic effect. A higher TI indicates a wider margin of safety for the drug.
Why monitor serum levels of vancomycin?
Monitoring serum levels of vancomycin is essential to ensure therapeutic efficacy and minimize toxicity. Since vancomycin has a narrow therapeutic index, measuring serum levels helps to maintain drug concentrations within the optimal range to effectively treat infections while avoiding nephrotoxicity and ototoxicity. Regular monitoring also aids in adjusting dosages based on individual patient factors, such as renal function.
What Types of medicines will need to be taken more frequently to ensure its blood concentration falls within the therapeutic range?
Medications with a narrow therapeutic index, such as warfarin, lithium, and certain anticonvulsants (like phenytoin or carbamazepine), often require more frequent dosing to maintain their blood concentrations within the therapeutic range. Additionally, short-acting medications or those with rapid clearance rates may necessitate more frequent administration to prevent subtherapeutic levels. Regular monitoring and dose adjustments are crucial for these medications to ensure efficacy and safety.
Why do penicillin have a better therapeutic index than other antimicrobial?
Yes these are the antibiotics which have the highest therapeutic index.. That too penicillin is exceptionally high... The only side effect which is considered significant from these two groups of antibiotics is Hypersensitivity reaction or allergis reaction which can be lethal also in some of them.. The reason is, both of these belong to a group of beta lactum antibiotics and they both have a protein structure and they are easily metabolised in the body.. If they ast on bacteria than they are antibiotics otherwise they are mere protein food, just like giving parentral nutrition... Hence they have a huge therapeutic index..
