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What is paradoxical hyperactivity?

Updated: 9/14/2023
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Paradoxical hyperactivity (PH) is a known complication of sedation in children, especially with barbiturates such as pentobarbital and phenobarbital. The accompanying inconsolable irritability and agitation, similar to behaviors reported in children with attention deficit hyperactivity disorder (ADHD), is uncomfortable for the child and anxiety-provoking for parents and health-care workers.

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