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When your brain feels it need the drug to keep going. This is probably the biggest part of an addiction.

Actually the physiological aspects of addiction are twofold. There is the initial physical need for the substance which will cause you to feel withdrawal symptoms such as:

Alocohol: shaking hands, nausea, headache, thirst, dizziness (basic hangover stuff) or hallucinations and seizures in those severely addicted (aka The DT's).

Opiates: Heroin, Oxies, etc. Nausea. cramping, sweats, itching, etc.

Then there are also the secondary symptoms that have to do with the brain chemistry trying to right itself after prolonged use. There will be mood swings, anxiety, irritability, depression, mania, etc. depending on the substance. Because people who are addicted can actually permanently change their brain chemistry after long term use of a drug these symptoms may never go away which is why anti-depressants and mood stabilizers (which are non-narcotic, non-addictive and don't get you high) are very useful for addicts trying to stay sober. This is also why studies have reported that up to 70% of those with an addiction have some form of mental disorder such as depression. Weather the mental disorder came first or the addiction is still being debated.

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