Some people love 9 millimeter, some people love .40 S&W, some people love .45 ACP, etc. It's strictly a matter of opinion, and very difficult to answer because different calibers are designed/intended for different things, and there isn't really any single "all-purpose" caliber. A .22 target pistol is a great small varmint gun, but a very poor choice for concealed carry. A .45 ACP is a great choice for concealed carry but a very poor choice for hunting squirrels. A .500 S&W is a great hunting gun for larger game, but a very poor choice for concealed carry, or squirrel hunting, etc.
Best to ask a gunsmith for help
It all depends on you, your pocketbook, your skills.
Can't be answered without knowing what caliber, intended use, make of firearm
Assuming you mean a bullet fired from a .22 caliber handgun, the answer is, yes, it can, but it depends on several variables.
Yes, colt makes a few different versions of the 22 caliber handgun such as the Woodsman, and Challenger.
It should be marked as to caliber on the barrel.
Its the size of the bullet that the gun is made for. its the caliber that a handgun uses
No.
.32 caliber. In a semi auto handgun, probably .32 ACP
Probably. It would likely refer to a handgun that fires a .45 caliber ACP, or .45 GAP or an older .45 caliber revolver round.
45 has the larger projectile. Size of the handgun will vary.
$489!!