Niagara falls/St. Catherines lies on the border but is relatively small.
(roughly 400,000 people)
Hamilton is about 45 min. down the shore and is the the closest major Urban Center. This area forms the southern end of the Grater Toronto & Hamilton Area
(roughly 8 million people)
While Fort Erie, Ontario, is directly across the river from Buffalo, Fort Erie is a town and not a city. Three Canadian cities (Port Colborne, Welland and Niagara Falls) would appear to be equidistant. Which one of them is closest would depend on the method of measurement. From downtown to downtown, the nearest Canadian city to Buffalo would be Port Colborne. However, if measured from the closest point on Buffalo's border to the closest point on a Canadian city's boundary, the winner would be Niagara Falls, Ontario.
Buffalo
Halifax harbour is the closest port city to Europe
Toronto.
Niagra Falls, Ontario, Canada
Washington
Toronto
Fubicktck
Buffalo (Buffalo Niagara - BUF) and Toronto (Lester B. Pearson - YYZ) are the two closest major airports to Niagara Falls. There are also regional airports nearby, in Syracuse and on Toronto Island.
The Canadian city closest to Virginia is Toronto, in Ontario, Canada. In addition, Niagara Falls is located in Toronto, Canada.
Niagara falls, i am supposing your asking about an American city, closest Mexican city would be Juares. closest begique city would be Oust end. and depending on what part of the US your coming from aswell. Juneau Alaska is close to the border.
Probably the closest major Canadian city to those coordinates is Winnipeg, Manitoba. It's exact coordinates are Latitude: 49° 52' 60 N, Longitude: 97° 10' 0 W.