Creatinine clearance test. This test evaluates how efficiently the kidneys clear a substance called creatinine from the blood.
chal nass
There is no need to fast for a bun and creatinine test.
Creatinine test. This test measures blood levels of creatinine, a by-product of muscle energy metabolism that, similar to urea, is filtered from the blood by the kidneys and excreted into the urine.
The creatinine test is used to diagnose impaired kidney function and to determine renal (kidney) damage.
no
In general, creatinine clearance is the removal of creatinine from the body. In renal physiology, creatinine clearance is the volume of blood plasma that is cleared of creatinine per unit time. Clinically, creatinine clearance is a useful measure for estimating the glomerular filtration rate (GFR) of the kidneys.1Creatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass).2The result of this test is an important gauge used in assessing excretory function of the kidneys.11. http://en.wikipedia.org/wiki/Creatinine_clearance2. http://en.wikipedia.org/wiki/Creatinine
Low clearance values for creatinine and urea indicate diminished ability of the kidneys to filter these waste products from the blood and excrete them in the urine. As clearance levels decrease, blood levels of creatinine and.
It detects problems at the level of the kidney, since this is a specific kidney function test.
chal nass
Creatinine clearance is a measure of kidney function. Patients are on dialysis because their kidneys do not function properly thus their creatinine clearance would be very, very low. Some patients may have some residual kidney function but their creatinine clearance would be less than probably 10 ml/min.
Low clearance values for creatinine and urea indicate a diminished ability of the kidneys to filter these waste products from the blood and to excrete them in the urine.
to find out kidney filteration rate.
There is no need to fast for a bun and creatinine test.
There is no need to fast for a bun and creatinine test.
Creatinine test. This test measures blood levels of creatinine, a by-product of muscle energy metabolism that, similar to urea, is filtered from the blood by the kidneys and excreted into the urine.
DefinitionThe creatinine clearance test compares the level of creatinine in urine with the creatinine level in the blood. (Creatinine is a breakdown product of creatine, which is an important part of muscle.) The test helps provide information on kidney function.See also:Creatinine - blood testCreatinine - urine testHow the test is performedThis test requires both a blood and urine sample. You will collect your urine for 24 hours, and then have blood taken.For information on giving a blood sample, see: venipuncture.For information on how to collect the urine sample, see: 24-hour urine collection.The samples are sent to a laboratory. The laboratory specialist measures the level of creatinine in both the urine and blood samples, and looks at how much urine you collected in 24 hours.The clearance rate is then calculated. The calculation is adjusted for your specific body size.The creatinine clearance appears to decrease with age (each decade corresponds to a decrease of about 6.5 ml/min./1.73 m2).How to prepare for the testIf the collection is being taken from an infant, a couple of extra collection bags may be necessary.How the test will feelThe urine test involves only normal urination and there is no discomfort. When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedThe creatinine clearance test is used to estimate the glomerular filtration rate (GFR).However, because a small amount of creatinine is released by the filtering tubes in the kidneys, creatinine clearance is not exactly thto the same as the GFR. In fact, creatinine clearance usually overestimates the GFR. This is particularly true in patients with advanced kidney failure.Normal ValuesClearance is often measured as milliliters/minute (ml/min). Normal values are:Male: 97 to 137 ml/min.Female: 88 to 128 ml/min.Note: Normal values ranges may vary slightly among different laboratories.What abnormal results meanAbnormal results (lower-than-normal creatinine clearance) may indicate:Acute tubular necrosisBladder outlet obstructionCongestive heart failureDehydrationGlomerulonephritisRenal ischemia (blood deficiencyRenal outflow obstruction (usually must affect both kidneys to reduce the creatinine clearance)ShockAcute renal failureChronic renal failureEnd-stage renal diseaseWhat the risks areThe risks of the test are minimal and are related to the blood draw process. Rarely, the following will occur:Excessive bleeding at blood draw siteFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)Multiple punctures to locate veinsSpecial considerationsFactors that may interfere with the accuracy of the test are as follows:Incomplete urine collectionPregnancyVigorous exerciseDrugs that can interfere with creatinine clearance measurements include: cimetidine, trimethoprim, and drugs that can damage the kidneys, such as cephalosporins.The creatinine clearance test should only be done for patients who are medically stable. Such patients may have a rapidly changing creatinine clearance, and therefore any result may be inaccurate.ReferencesBazari H. Approach to the patient with renal disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 115.
Normal creatinine clearance in most people is over 60 mL/min, however, in pregnancy it is increased by as much as 50% because of increased GFR and renal plasma flow.