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The biggest difference is their potency - Demerol is a DEA Schedule 2 controlled substance, while Vicodin (Hydrocodone) is a Schedule 3 drug. Demerol (generic name Meperidine), being a Schedule 2 drug, is more tighty regulated - you cannot get refills, and each fill must be obtained with a new prescription each time. Also, many doctors don't like to prescribe Demerol because it's been associated with potential seizures. Personally I think it's that they're too chicken - I've used it for years with no problem.

Vicodin, being a Schedule 3 drug, can have refills on one prescription and isn't as tightly regulated, and is more often prescribed for most acute pain patients.

Pharmacologically, they're both morphine derivatives, though Demerol is a lot stronger. It's also more often given as an injectable or through an IV stream when a person is in the hospital.

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14y ago
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11y ago

Methadone is the stronger of the 2; Methadone is a Schedule II opiate, where Vicodin is only a Schedule III.

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10y ago

It depends on the strength of the Norco. the common yellow Norcos are 10mg hydrocodone and 325mg acetaminophen. Vicodin ES is 7.5mg hydrocodone and 750mg of acetaminophen.

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Q: What is difference between Demerol and Vicodin?
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Is Demerol the same as vicodin?

No. Vicodin isn't as dangerous.


What is the difference between vicodin 5 and vicodin 7.5?

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Is Demerol more powerful than vicodin?

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Is Dilaudid stronger than Vicodin?

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What is the difference between Hydrocodone-APAP and Vicodin?

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