What is the distance between San Diego CA and San Francisco CA?

Answer 1

About 502.30 miles according to MapQuest.
510 miles taking this route:

1. Take I-5 NORTH from San Diego to I-580 WEST to San Francisco at EXIT 446, near Tracy. To bypass LOS ANGELES, take I-405 NORTH (EXIT 94 off I-5).
2. Take I-580 WEST to I-80 WEST to SAN FRANCISCO at EXIT 19A in OAKLAND.
3. Take I-80 WEST to SAN FRANCISCO via the BAY BRIDGE (toll bridge).