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That depends a bit on what your proteoglycans are and where in the body they are. I'm currently working the musculoskeletal field. I'm pretty sure I've seen it suggested that proteoglycans can act as lubricators and allow fibrils within organs such as tendons to slip past each other smoothly. I also know that the large proteoglycan aggrecan is a vital component of hyaline cartilage. It contains lots of negatively charged polysaccharide side chains which attract and retain water. This contributes to cartilage's ability to resist compressive forces.

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Q: What is the function of proteoglycans?
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