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Buffer systems help to maintain constant plasma pH. There are three buffer systems - Protein buffer system, phoshate buffer system and bicarbonate buffer system. Among this, bicarbonate buffer system is the most predominant. Buffers function as "shock absorbers" that accept excess H+ ions or OH- ions and keep blood pH constant. For example, if there is an increase in acidity of blood due to excess HCl (a strong acid), then NaHCO3 (Sodium bicarbonate) will buffer it to a weak acid (H2CO3).

HCl+NaHCO3 = NaCl+H2CO3

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Hemoglobin

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Q: What is the major buffer system in human blood?
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