Nothing. If you mean "open Pandora's box," however, it means to release a lot of trouble by being too curious. It is from a myth.
Pandora was forbidden to open the box.
That would be "crack you up" - the image is of you laughing so hard that your sides crack open.
Pandora was giving it to her husband Epimetheus.
when pandora stole the key and open the box
On Earth.
Pandora got her box from Hermes who said never to open it.
Pandora's box was a box containing all the troubles of the world which Pandora was told not to open. When she did open it all the troubles got out and did horrible things. Thus when someone says "If you investigate that you will be opening a Pandora's box", they are saying that if the subject is investigated a lot of bad things will be discovered.
Yes, Marie Curie opened a Pandora's box.
Pandora was very curious and Zeus gave her a box and told her not to open it. Eventually, Pandora opened it, releasing all of the evils in the world.
Epimetheus - the brother of Prometheus- was the husband of Pandora. Pandora was given the box by the gods and was told by Hermes not to open it.
no
Yes