What is the mechanism of action of methylphenidate?

Answer 1

Though the mechanism of action of cocaine is not fully understood, it is thought to bind to and block the dopamine transporter protein (DAT). Blocking the action of this protein increases the concentration of dopamine in the synaptic cleft, thereby producing the characteristic effects of cocaine (such as stimulation and euphoria). Cocaine also affects serotonin receptors, sigma receptors, and sodium channels, though these actions play less of a role in its pharmacology.

Answer 2

Sympathomimetic drugs act directly as agonists of both alpha and beta adrenergic receptors. The act indirectly by causing the release of both dopamine and norepinephrine from presynaptic terminals.