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Fever is caused by infection .noninfectious causes are cancer,collagen vascular diseases,granulomatous diseases etc.Infectious causes releses pyrogens which produce pyrogenic cytokines, and non infectious causes directly stimulates release of pyrogenic cytokines, which go to vessels supplying hypothalamus(lamina ventricularis), where they produce PGE2 from endothelium of blood vessels,which makes thermostat of hypothalamus in a higher level, which causes fever.
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