What is the safest pain reliever to take when you are drinking alcohol?
None, as it is dangerous to mix any form of medication, be it
prescriptive or non-prescritive , with alcohol. If you must take a
pain reliever, however, the safest choice would be a low dose (one
pill) of Aleve, as it has less of a detrimental effect on the liver
and kidneys than Tylenol and the other NSAIDs.