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Hurricanes cause the most damage right at landfall when rain, winds, and storm surge have the greatest damage potential. After landfall the hurricane quickly weakens.
Reverse / thrust faults at convergent boundaries typically cause the largest Earthquakes and so have the potential to cause the greatest amount of damage.
Ozone depleting substances cause damage to the ozone layer. CFC's are greatest of them.
High winds can cause the most direct damage, especially on non-reinforced structures. However, floods from heavy rains or tidal surge have the greatest potential for fatalities and general damage.
A hurricane's storm surge causes devastating flooding. That typically constitutes the greatest damage from the storm. If the storm makes landfall in a non-populated area, the storm surge damage may be negligible compared to the spawned tornados and straight-line winds causing disruption of utilities even at at a distance from the landfall.
the greatest damage is cause by fires that get started by it all (c)
Tracoma, a serious eye infection and the greatest single cause of blindness by an infectious disease.
blast wave
Nuclear weapons cause the greatest damage in explosion. This will affect even the atmosphere for a very long period of time.
diseases
accumulation of debt
accumulation of debt
Hurricanes cause the most damage right at landfall when rain, winds, and storm surge have the greatest damage potential. After landfall the hurricane quickly weakens.
selfishness
A rating of EF5 is reserved for the tornadoes that cause the greatest degree of damage.
Reverse / thrust faults at convergent boundaries typically cause the largest Earthquakes and so have the potential to cause the greatest amount of damage.
Tire wear is the most common "damage". The most common cause is use, but the greatest cause of tire wear is an improperly aligned vehicle. This is known as excessive tire wear. Excessive tire wear is wear that is in excess of what would be expected for the actual miles of use. Another cause of excessive tire wear (even on a properly aligned vehicle) is improper tire inflation. Over inflated tires cause the tire to wear in the center of the tread and under inflated tires will wear the outer portion of the tread. To focus more on damage as a single incident verses wear as an ongoing process. Severe impacts such as hitting a curb or a large pothole would top the list. The lower a tires aspect ratio the greater the potential for damage from this type of impact. The question needs clarification.