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Firstly, sodium ions would never get past the membrane without a carrier protein, ions (charged atoms) don't go through the membrane on their own. If the cell has a protein carrier capable of transporting the sodium ion, if there's water in the environment to encapsulate the ion so that it can go through and if the cell has ATP to spend then it shouldn't be too difficult.

Secondly, oxygen and carbon dioxide gas? There shouldn't be gas in your bloodstream to begin with. Non gaseous O2 and CO2 cannot diffuse passively into cells quite easily based on concentration gradients. They're small but apolar molecules.

Alcohol comes in many forms, you have bigger and smaller alcohol molecules. It's polar, and so is the part of the membrane that is facing the outside and inside of the cell, but the middle part is apolar, so any molecule such as alcohol might have a few problems going through there, especially the bigger molecules.

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Q: What molecules have the most difficult time passing through the cell membrane alcohol or oxygen gas or carbon dioxide gas or sodium ion?
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What can not cross the semipermeable membrane?

sugar molecules


What are 3 molecules that pass through the lipid bilayer of the cell membrane?

oxygen, carbon dioxide, and water


Which substance could pass through the cell membrane readily?

Small molecules, such as water, oxygen, and carbon dioxide.


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Carbon dioxide, oxygen and some nonpolar molecules diffuse easily.


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Materials that can cross the cell membrane include small non-polar molecules like oxygen and carbon dioxide, as well as small polar molecules like water. These molecules can freely pass through the lipid bilayer of the membrane due to their small size and compatibility with the hydrophobic environment of the lipid tails. However, larger molecules and charged ions require specific protein channels or transporters to cross the membrane.


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