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Antidiuretic Hormone (ADH) is synthesized by nuclei in a particular part of the hypothalamus called the paraventricular nucleus. Once ADH is synthesized it is transported down the axons of the paraventricular nucleus of the hypothalamus to the posterior pituitary where it is then released into the blood circulation. ADH synthesis is increased during dehydration as it acts on the kidneys to prevent water excretion. This is achieved by effectively making a region of the kidneys more permeable to water, among other things. Disorders of the hypothalamus can cause Central Diabetes Insipidus, where the bdy is unable to manufacture ADH and you will quickly become dehydrated if water consumption is stopped.

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Q: What part of the body does the antidiuretic hormone come from?
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