I think her biggest challenge was one that she couldn't meat. It was her failed attempt to manipulate Octavian into feeling sorry for her and forgiving her.
Cleopatra's biggest enemy was the Roman Empire who wanted to invade and take over rule in Egypt.
The biggest Egyptian ship was 330 feet long and pulled Cleopatra's needle to its original spot.
the suitors
Yes, her biggest mistake or mistakes, was pinning her hopes on two individuals, Caesar and Antony. Both men failed to an extent, and Cleopatra failed with them.
Octavian was Cleopatra's biggest problem. He was a different sort of Roman than she had been accustomed to dealing with. He didn't flatter her as the others did, and he certainly didn't need her money after the conquest. In fact, when he went to interview her, much to her frustration, he would not even look at her. He refuted all her excuses for her conduct and her trying to put the blame on Antony. She simply did not know how to deal with him.
Octavian was Cleopatra's biggest obstacle.
The biggest challenge for him is not sounding horrible and repetitive. It is a challenge he still hasn't overcome.
her family
Galileo's biggest challenge that he has faced is building telescope.
her biggest challenge was facing all of the lies and splitting up of her family
one of the most biggest challengings was fighting for what they wanted.
Cleopatra's biggest enemy was the Roman Empire who wanted to invade and take over rule in Egypt.
something
Pneumonia
lie
The Panic of 1837 was Van Buren's biggest challenge. The resulting economic slump was no doubt the biggest factor in his defeat for re-election in 1840.
The biggest challenge for most people in Zambia is simply to survive.