What weapons did Hernando De Soto use?

Answer 1

The musket, i'll use a gun you use a bow, who wins ?

The answer above is a common misconception, whilst a musket or harquebus as the SpanIsh had then is great in a one on one situation, they are very slow to reload and useless when you are outnumbered as the conquistadors were.

The Horse and Steel were Cortes best weapons.

Answer 2

crossbows, arquebus, steel swords, lances (on horseback), war dogs (greyhounds and mastiffs), and cannons (not really used except for showing strength)

Answer 3

pistol shotgun aka47