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If you mean a file with the extension *.reg, when you double click on it the operating system will ask you "Do you want to add information in the registry?" (or something like that). If you confirm you will change the registry. You have to be extremely careful when you are using such files because it can cause irreversible damage of the registry and as result the death of the operating system.

If you mean SAM file. Then nothing will happen. The operating system will not allow you to modify the file. You cannot even copy it.

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Q: What will happen when you double click the registry file?
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