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New fat cells, or lipocytes, are created only when all currently existing lipocytes within an organism are saturated with fat. This enlargement of a cell is known as hypertrophy and results in fat cells dividing and creating new fat cells known as hyperplasia. The average weight of a fat cell is 0.6 micrograms and hyperplasia occurs when fat cells become 4-6 times larger than their average size. Men with bodyfat greater than 19% and woman with bodyfat of greater than 25% may become at risk for hyperplasia.

This is why once you become obese it is much harder to lose weight. At that point you have more fat cells to contend with than the average person who did not experience hyperplasia. It is extreamly difficult to decrease the number of fat cells once you have them. It is very important to not to allow hyperplasia to happen in the first place. Moreover, you gain most of your fat cells during adolescence until you finally finish puberty. At that time you more or less reach your set point of fat cells you carry with you into adulthood. This is why overweight kids have a much harder time controlling weight as adults. They simply start off adult life with more fat cells to have to deal with. It is also the reason why dieting is much harder for obese people. The bottom line is do not let yourself get so fat that your fat cells increase or you will forever have a much harder time controlling weight.

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