Never! As long as everything is working well health wise, men never stop producing fertile sperm until they die. There are men in their seventies and reports of men in their eighties who have gotten their woman pregnant.
So as long as everything in the health department is working fine, your sperm cells should be good too until your death.
However, if you take certain street drugs or start a female hormone regimen, you can permanently lose your ability to produce sperm. One clue to this is a decrease in testicle size.
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