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What are normal results for a Bence Jones protein test?
Normal results for a Bence Jones protein test should show no detectable levels of Bence Jones protein in the urine, indicating a healthy kidney function and no abnormal protein excretion. If Bence Jones protein is present in the urine, further investigation may be needed to determine the underlying cause.
What is a Bence Jones protein test?
Bence Jones proteins are small proteins (light chains of immunoblobulin) found in the urine. Testing for these proteins is done to diagnose and monitor multiple myeloma and other similar diseases.
What is the best specimen for a Bence Jones protein test?
The best specimen for a Bence Jones protein test is a 24-hour urine sample. This allows for the most accurate measurement of protein excretion over a full day, which is important for detecting and monitoring conditions such as multiple myeloma.
Discuss the meaning of the positive and negative test for bence Jones?
Bence Jones proteins are present in the urine of a patient suffering from multiple myeloma. Positive test means they are present in the urine and so the person probably has multiple myeloma, and if it is negative it means they are absent and so the person does not have the disease
How long does a bence Jones protein test take?
heat and acetic acid test
What is the method of Bence Jones Protein in the urine test?
put 5ml of concentrated hydrochloric acid in a clear tube.carefully add 3ml of test urine to make a good interface without mixing the two.a white curdy precipitate at the interface indicates presence of bence Jones protein
What is the purpose of a Bence Jones protein test?
.Multiple myeloma, a tumor of plasma cells, is the disease most often linked with Bence Jones proteins.Physicians use Bence Jones proteins testing to diagnose the disease as well as to check how well the disease is responding to treatment.
What is the name of the test for protein in the urine?
The name given to a urine protein test is the Bence-Jones. It requires a clean catch urine sample of between one and two ounces. It can be used to test for things such as lymphoma, amyloidosis and chronic lymphocytic leukemia.
How do you collect specimen for benze-jones protein test?
To collect a specimen for a Bence Jones protein test, a 24-hour urine collection is usually required. You will be provided with a container to collect all urine passed during a 24-hour period, starting with an empty bladder and ending with a final collection at the same time the following day. The urine specimen is then sent to a lab for analysis to measure the presence of Bence Jones proteins.
What are abnormal results in a Bence Jones protein test?
Bence Jones proteins are present in 50-80% of people with multiple myeloma.Certain nonmalignant diseases, such as rheumatoid arthritis.High doses of penicillin or aspirin before collecting the urine can give a false positive result.
How do you do Heat test for Bence-Jones protein?
Heat test for Bence-Jones protein involves heating a urine sample to 60-100°C for 5 minutes, followed by observation for the presence of precipitate. A positive test results in the formation of a gelatinous or flocculent precipitate, indicating the presence of Bence-Jones protein. This test is commonly used to screen for multiple myeloma.
Bence-Jones protein - quantitative?
DefinitionA quantitative Bence-Jones protein test measures the specific level of abnormal proteins (Bence-Jones proteins) in your urine.Alternative NamesImmunoglobulin light chains - urine; Urine Bence-Jones proteinHow the test is performedA clean-catch (midstream) urine sample is needed.Men or boys should first wipe clean the head of the penis. Women or girls need to wash the area between the lips of the vagina with soapy water and rinse well.As you start to urinate, allow a small amount to fall into the toilet bowl (this clears the urethra of contaminants). Then, in a clean container, catch about 1 to 2 ounces of urine and remove the container from the urine stream. Give the container to the health care provider or assistant.In infants, thoroughly wash the area around the urethra. Open a urine collection bag (a plastic bag with an adhesive paper on one end), and place it on your infant. For boys, the entire penis can be placed in the bag and the adhesive attached to the skin. For girls, the bag is placed over the labia. Place a diaper over the infant (bag and all).Check your baby frequently and remove the bag after the infant has urinated into it. For active infants, this procedure may take a couple of attempts -- lively infants can displace the bag. The urine is drained into a container for transport back to the health care provider.How the test will feelThe test involves only normal urination, and there is no discomfort.Why the test is performedBence-Jones proteins are relatively small and are filtered out by the kidneys. This test is done to help diagnose medical conditions that lead to protein in the urine (proteinuria).Your doctor may also order this test when your urine protein level is high or if you have other signs of multiple myeloma.Normal ValuesA normal result means no Bence-Jones proteins are found in your urine.What abnormal results meanBence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma.An abnormal result may also be due to Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia, or amyloidosis.Special considerationsUrine immunofixation is the best test for detecting Bence-Jones proteins.ReferencesMcPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa: WB Saunders; 2006.Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingston; 2008.Reviewed ByReview Date: 06/02/2010David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
