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Only when it's called for or absolutely necessary. Most meds and/or vaccines recommend SubQ shots over IM because of the slower release rate that allows the medicines to take effect. There are certain meds that say you can give IM, but they also have dosage rates for SubQ, and more than likely SubQ is higher recommended than IM. Check with your vet on that though.

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Q: Where should intramuscular shots be placed on a cow?
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