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When a person picks up a box off the floor, the primary muscles used include the quadriceps, hamstrings, and gluteal muscles, as they help extend the hips and knees during the lifting motion. Additionally, the muscles of the back, particularly the erector spinae, play a crucial role in maintaining proper posture and stability. Core muscles, such as the rectus abdominis and obliques, also engage to support the spine and assist with balance during the lift.

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