Spider-Man has an entire full rouge gallery. It would be impossible to name them all. However, Spider-Man's arch-enemies would include Doctor Octopus, Green Goblin, and Kingpin.
Here is 20 of his greatest supervillians!
Hydro-Man
Not just a Spider-Man foe! A Sandman foe as well! He's basically Sandman except instead instead of sand he's water. And he got more well known since the animated series put him in the spotlight instead of Sandman.
Morbius
Nicknamed the Living Vampire! He started the vampire era in the Marvel universe! He has been a dangerous Spider-Man villain at first. He's super strong and he has lust for blood and Spider-Man has been his target now and then.
Chamelion
A master of camouflage and Spider-Man's original villain. He has also fooled other people that Spider-Man was bad.
Shocker
Shocker has been close to defeating Spider-Man now and then. But sometimes an easy villain to Spider-Man as well. He is well known for his good looking yellow suit that gives him his power!
Rhino
One of Spider-Man's strongest foes. But also one of his dumbest. This guy could even Hulk a run for his money. Almost!
Mysterio
This guy likes to play with Spider-Man's mind! He's a master illisionist with special effects.
Kraven
One of the greatest hunters in the Marvel universe. His goal was to catch Spider-Man and he finally succeeded at one point.
Scorpion
Made to take place of Spider-Man as a superhero. But then turned to crime and has a hatred over Spider-Man. So making him a deadly villain!
Vulture
A pretty bad Spidey villain! He killed Aunt May's fiance and even stole Spider-Man's youth for a time.
Jackal
A dangerous and creepy looking villain. This guy freakin cloned Spider-Man and also fooled him to think he wasn't Spider-Man.
Kingpin
Probably more well known as a Daredevil villain but originally a Spider-Man villain. He has done some damage to Spider-Man. Like almost killing Aunt May!
Morlun
Spider-Man's strongest and most supernatural villain. He's also the newest. He almost killed Spider-Man more than once even gouging his eye out!
Electro
A very dangerous Spider-Man villain with a dangerous power. You can't even touch him without being electrocuted.
Hobgoblin
A cunning and deadly Spider-Man foe! Almost just as dangerous and even more creepier looking than Green Goblin.
The Lizard
Not only dangerous for his hatred of humanity. But when Dr. Connors (alter ego of Lizard) is not the Lizard he is a good friend that Spider-Man can't harm!
Sandman
You can't even harm this guy by one punch! But he can harm you by shaping his arm to a hammer. Sandman has been a foe of Spider-Man for quite a while.
Carnage
Spider-Man's darkest and deadliest villain. He's nothing but pure evil and doesn't care who he hurts or kills.
Doctor Octopus
One of Spider-Man's oldest and most fought arch nemesis. Doctor Octopus have been around. Doctor Octopus has been the leader of the Sinister Six, (Spider-Man's most deadly and famous villain group) engaged to Aunt May, to even almost even killing Spider-Man. He keeps getting more and more sinister every time they meet.
Venom
A very dangerous Spider-Man villain and the most popular. Although some consider him an anti- hero. He has the same power as Spider-Man and then some. Spider-Man can't sense him with his Spider Senses. Venom's main goal was to ruin Spider-Man's life. Good thing he hasn't done it yet but he has came close.
Green Goblin
If there is one who came close to ruin Spider-Man's life it is the Green Goblin. He has killed Spider-Man's girlfriend, Gwen Stacey and was even involved in the clone saga! He also was a leader in the Sinister Twelve and even possesed his best friend ( Harry Osborn [ Green Goblin II]) against Spider-Man!
A list of other villians that are more minor!
Burglar (Without him there wouldn't be a Spider-Man!)
Tombstone
The Enforcers
Dr. Doom(Mosty a Fantastic Four villain but he's been around!)
Kaine(1st clone of Spider-Man and most dangerous!)
Manwolf
Hammerhead
Boomerang
Spenser & Alistaire Smythe & their Spider-Slayers! (They really have bugged Spider-Man for a long time!)
Jack 'O' Lantern
Scarecrow
Will 'O' Wisp
Calypso (Kraven's lover!)
Tarantula( I and II)
Hobgoblin II
Demogoblin (An Hobgoblin possesed by a demon!!!!)
Green Goblin II (He's kind of a big deal as well! Mostly because he's because he's Spider-Man's best friend. He's called New Goblin in the movie of course! )
Kraven II
Beetle
Puma ( Not really a foe anymore! He has respect over Spider-Man!)
Prowler
The Rocket Racer (Actaully he turned into a friend at the end but he was an enemy!)
Silvermane
Rose
Carrion (1, 2 and 3)
Also he's not a villain but one of the deadliest foes!
J. Jonah Jameson (He is proof pen is mightier than the sword! He hates Spider-Man just as much as villians do! And do anything to harm him.)
Well spider man has a lot of foes but some of the popular ones are : Green Goblin, Sandman,
And Venom.
Dr Oto Octavius; Carnage, Venom, Demo Goblin, Green Goblin, Hob Goblin, Sandman, Rhino, Mysterio
He has many. I will just name the main three: Green Goblin aka Norman Osborne, Doctor Octopus aka Dr. Otto Gunther Octavius, Venom aka Eddie Brock
venom,carnage,toxin
at first his enemy was doc oc but they basically became friends then the machine doc oc created was unstable so now the enemy is the machine so i guess the machine was the enemy in the end
Vanir
No. Bizzaro can be a nuisance & antagonist but he can't be described as an "arch-enemy", certainly not in the same manner as Lex Luthor or Darkseid.
TV Tropes I believe list the Thinker as the arch-enemy of the 1940's Flash, Gorilla Grodd as the arch-enemy of the Silver Age Flash, Professor Zoom as the arch-enemy of the Flash in the Bronze Age, then Vandal Savage, Abra Kadabra, Captain Cold and Zoom II as arch-enemies of Wally West at one point or another. His arch-enemy is usually considered to be Cold or Professor Zoom though.
sabretooth
Arch Enemy was created in 1996.
Most people who have an arch-enemy, the arch- enemy is a person who has done them wrong. To have an animal as an arch Ðenemy is considered to be slightly abnormal.
An arch enemy is a particularly strong or powerful enemy.
Arch Enemy Entertainment was created in 2004.
Zatanna's arch enemy pre new 52 is Brother Night.
He-Man's skull-faced arch enemy is Skeletor.
Manifesto of Arch Enemy was created on 2009-02-27.
ignore both of them your arch enemy and the bff that your enemy turned aganist you.Get away from them
Bizzaro doesn't have an arch enemy, he just wants to take over the earth.
at first his enemy was doc oc but they basically became friends then the machine doc oc created was unstable so now the enemy is the machine so i guess the machine was the enemy in the end
Well, technically, they're the same thing. But I suppose you could say that an arch enemy is a forever enemy, as an enemy may just be your enemy for a few days.
Arch Enemy: A hero's worst enemy, especially in a work of fiction. Mortal Enemy: An enemy who wants to kill a hero. source: http://encyclopedia.thefreedictionary.com/