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Why and hpw RBCs die?

Updated: 9/17/2023
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14y ago

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RBC's die because they eject their nucleus during their formation in order to make more room for hemoglobin. Without a nucleus they are unable to make repairs and due to the stresses of traveling within the cardiovascular system. As a result they last on average about 120 days.

Worn out RBC's are removed from circulation in the spleen and liver. The heme and globin portions of hemoglobin are split apart. The globin is broken down into amino acids which can be used to synthesize other proteins. Iron is removed from the heme portion and used to synthesize new heme molecules. The non-heme portion goes through a series of chemical transformations and eventually ends up as something called sterocobilin which is what gives feces it's characteristic brown color.

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