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One factor may be the great fire of London which burned for 3 days and destroyed huge swathes of the city. It killed many of the plague infested rats and fleas and following the destruction of so much housing people were encouraged to leave the city so it temporarily became less overcrowded.

The number of deaths resulting from the fire has often been said to be remarkably low, in single figures. However, the fate of the poor was not recorded and the fire burned hot enough to cremate its own corpses so the real figure is probably in the hundreds, maybe thousands.

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13y ago
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Q: Why did cases of the plague decrease in 1666?
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