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individual cells are practically transparent, that is, light will pass directly through them and when viewed under a normal light microscope, almost nothing will have enough contrast for you to descern the different structures. Staining gives colour to the sample, increasing contrast between the cells and the surroundings, hence making it easier for you to observe them under the microscope. Usually stains do not simply give colour to the cell in general but bind to specific structures within the cell, making it easier to view specific organelles. However, staining is not required for all types of microscopy techniques. Some microscopy techniques required a completely different method of sample preparation, such as in electron microscopy.

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15y ago
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16y ago

A lot of tissue is the same colour and density: have you ever look at glass under water, it is much the same thing. Staining things makes different things take on colour and they can be seen much more clearly. I believe the first medical staining was done by Doctor Erhlich in working with the tuberculosis bacterium.

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9y ago

Stains are incredibly useful for viewing cells due to their inherent transparency because of their size. The coloring contrasts with the light in the background, allowing the human eye to perceive the cells more clearly.

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11y ago

Staining adds contrast to cell structure and allows us to distinguish to that structure.

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12y ago

Some structures and cells are not visible without staining. Staining can also help to identify certain structures (as some structures will be more strongly stained than others).

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Q: Why do biologists use stains to study cells?
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