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Familial AD cases associated with presenilin mutations only account for a small proportion of AD cases. The physiological roles of presenilins are diverse and not completely understood. However, they play a role in the metabolism of the amyloid precursor protein (APP). Presenilin mutants are thought to decrease the metabolism of APP, but increase the proportion of specific amyloid beta (1-42) and truncated amyloid beta (x-42) alloforms. These types of proteins are prone to aggregate with one another, and form plaques (i.e., a common neurological hallmark of Alzheimer's disease). The pathological role of plaques and the intermediate stages in their formation is debated, however research suggests that smaller and more soluble amyloid beta aggregates are potent neurotoxins which may cause the initial stages of synaptic deterioration in disease.
What else can I help you with?
Three genes Presenilin-1 gene on chromosome 14 Presenilin-2 on chromosome 1 and APP on chromosome 21 are responsible for more than of the early onset of familial Alzheimers?
90% of early-onset familial Alzheimer's disease cases are caused by mutations in the Presenilin-1 gene on chromosome 14, the Presenilin-2 gene on chromosome 1, and the amyloid precursor protein (APP) gene on chromosome 21. Mutations in these genes disrupt the processing of amyloid precursor protein, leading to the accumulation of amyloid-beta plaques in the brain, a hallmark of Alzheimer's disease.
What can cause memory loss and confusion?
alzheimers
Can Ambien cause alzheimers?
I doubt it. It sure can make you feel like you've got alzheimers if you take a lot. LOL
Does Xanax xr cause alzheimers?
No. Xanax XR does not cause alzheimer's disease.
Why does a shortage of transmitter substance could can cause alzheimers disease?
jaja yes
Ruling out dementia and alzheimers what can cause hallucinations in elderly?
Don't neglect the possibility of badly managed medication.
Can oxygen therapy cure alzheimers disease?
There is no cure for Alzheimers
Is grey matter a disease of the brain that would cause alzheimers?
Gray matter is a normal part of the brain, not a disease.
How exactly does a alzheimers test work?
An alzheimers test can be a timely process. This website will help you: http://www.ynhh.org/neuroscience/alzheimers-dementia.aspx?gclid=CKPBrY2s_akCFQ2A5QodSiLZ1Q
Sophia is being evaluated for non-Alzheimers dementia What are a few areas her physician might explore in seeking the cause for her condition?
red
Can stress cause alzheimers disease?
Nobody knows exactly what causes it, but stress probably doesn't. It can make the symptoms worse, however.
Is there an alzheimers care center in Augusta?
There are several alzheimers care centers in Augusta. They offer complete services to care for alzheimers patients, with good reviews from family and friends.
